Mycology Research Laboratories Ltd.
GMP and 100% organic certified.
Chinese name: Song Rong ("Pine mushroom"), 松茸
Japanese name: Himematsutake
Botanical name: Agaricus subrufescens Peck, Agaricus blazei Murrill
English name: Reddish Psalliota, God's mushroom
Recommended dose: 3-6 tablets per day
What is Blazei?
Agaricus subrufescens Peck/Agaricus blazei Murrill, ABM for short, is found in various parts of the world, including southeastern Tibet, southwestern Yunnan and western Sichuan in mainland China, Taiwan, Japan, Israel, Hawai, northeastern North America, Sweden, and in the rainforests of Brazil.
In addition to its anti-oxidant actions it has also attracted the attention of scientific researchers for its immune-strengthening, anti-allergic, anti-diabetes and anti-viral actions.
It has also been prized as a gastronomic, edible mushroom.
Chemical constituents of Blazei:
Agaricus subrufescens Peck/Agaricus blazei Murrill displays a well-balanced concentration of vitamins, minerals, amino-acids as well as a high proportion of polysaccharides. Defined peptide-glucans, in particular 1-4 alpha-D-glucan, 1-6 beta-D-glucan, ergosterin (the precursor of vitamin D), and a compound referred to as A-1 have been specified as the principle active ingredients of Agaricus blazei Murrill in terms of therapeutic efficacy 1.
Blazei viewed as Traditional Chinese Medicine herb: The Chinese herbal medicine actions of Agaricus subrufescens Peck/Agaricus blazei Murrill show characteristics of belonging to the following categories:
Tonify Source Qi
Resolve Fire Toxins
For example its role in improving insulin resistance in diabetes type-2 patients 12 suggests that at least part of its action is to replenish the Yin; insulin tends to produce signs and symptomes of Yin Deficiency in patients who use it. This conclusion is partially reinforced by the fact that a very common component of diabetes pathology, when subjected to a Chinese medicine differential diagnosis, is Deficiency of Yin of various kinds.
In common with many mushrooms and fungi Agaricus subrufescens Peck/Agaricus blazei Murrill has notable anti-oxidant properties 8. Leaving aside the bio-chemical descriptions of these properties, at least part of their action in this respect falls within the category of Invigorate Blood without injuring the Yin. Blazei not only Invigorates Blood without injuring the Yin, but also seems to actively Nourish Yin.
Therefore accurate application of Blazei-MRL can be facilitated by directing it to those patients whose Chinese medicine differentiation incorporates at least some element of Yin Deficiency, or in cases where it is necessary to Invigorate Blood without injuring the Yin.
Takaku T, Kimura Y, Okuda H: Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr. 2001 May;131(5):1409-13.
Kimura Y, Kido T, Takaku T, Sumiyoshi M, Baba K: Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions. Cancer Sci. 2004 Sep;95(9):758-64
Bernardshaw S, Lyberg T, Hetland G, Johnson E: Effect of an extract of the mushroom Agaricus blazei Murill on expression of adhesion molecules and production of reactive oxygen species in monocytes and granulocytes in human whole blood ex vivo. APMIS. 2007 Jun;115(6):719-25.
Bernardshaw S, Hetland G, Ellertsen LK, Tryggestad AM, Johnson E: An extract of the medicinal mushroom Agaricus blazei Murill differentially stimulates production of pro-inflammatory cytokines in human monocytes and human vein endothelial cells in vitro. Inflammation. 2005 Dec;29(4-6):147-53
Gao L, Sun Y, Chen C, Xi Y, Wang J, Wang Z: Primary mechanism of apoptosis induction in a leukemia cell line by fraction FA-2-b-ss prepared from the mushroom Agaricus blazei Murill. Braz J Med Biol Res. 2007 Sep 24; [Epub ahead of print]
Grinde B, Hetland G, Johnson E: Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection. Int Immunopharmacol. 2006 Aug;6(8):1311-4.
CH, Liao YL, Lin SC, Hwang KC, Chou P: The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med. 2007 Jan-Feb;13(1):97-102
Manufacturing Process Blazei-MRL is not an extract but instead contains both the mycelium and the primordia (young fruiting bodies) of Agaricus blazei grown aseptically into a biomass. The biomass is then manufactured into tablets, each containing 500mg.
Cultivation Process of Blazei-MRL MRL Ltd.´s Agaricus blazei powder contains both mycelium and primordia (young fruit body) cultivated into a biomass that is grown on a sterilised (autoclaved) substrate.
This cultivation process ensures the powder is free from contamination by other fungi and that pesticides and heavy metals are absent.
The cultivation system is proprietary, allowing for standardised production of Agaricus blazei. The powder biomass is then sealed in plastic containers.
Certified Organic (USA & EU) The fungal biomass Agaricus Blazei that comprises Blazei-MRL is certified 100% Organic in the United States by Quality Assurance International (Certificate No. 103491-A).
In December of 2005, MRL powder gained EU organic certification in accordance with EU Council Regulation (EEC) No. 2092/91 by Quality Assurance International (Certificate No. 105493-A).